Reversible Cell Injury

If ischemia or hypoxia is for short time duration then effect on cell can be reverting back to normal condition is called RCI.

 Some condition we are seeing in biochemical  & ultra structural in the presence of RCI

1) decrease generation of cellular ATP

2) Intra cellular lactic acidosis

3) Damage to plasma membrane pumps

4) Reduced protein synthesis

(1) decreased generation of cellular ATP :-

All living cell require continuous supply of oxygen to produce oxygenated blood is also required for all cells.

 But when adequate O2 supply to cell then it can be reverting back to normal condition .

(2)Intra cellular lactic acidosis :-

       

(3) Damage of plasma membrane pump:-

 Cellular fatty acids which are required for continuous repair of cell membrane .

(a) failure function of Na+ k+ ATP are pump:-.

(b)            Failure of Ca pump:-

Membrane damage cause disturbance in the calcium ion. exchange a cross 

   Exam calcium move in cell Particularly in mitochondria causing swelling & deposition of  phaspholipid rich amorphous densities

 

4)Reduction of protein synthesis